Argireline is a hexapeptide composed of short chains of amino acids. It works in a way similar to botulinum toxin. It achieves its paralytic effect by rapid and irreversible blockade of neuromuscular transmission. After local application, it is actively involved in complex physiological processes of tightening facial skin muscles. Inhibits the mechanisms responsible for wrinkle formation.. Acetyl hexapeptide-8 is a fragment of SNAP-25, a substrate of botulinum toxin (Botox). It manifests itself after passing through the skin barrier. It penetrates to the viable epidermis (keratinocytes), basal layer (melanocytes, nerve endings), dermis (fibroblasts) and hypodermis (adipocytes). It binds to cellular receptors. A super lipid (called a vesicle) releases neurotransmitters at synapses by sending a signal to the muscles. Three proteins, which make up the so-called. SNARE complex, are crucial for the final phase of the process of exocytosis and muscle contraction. Acetyl hexapeptide (argireline) mimics one of the proteins in the SNARE complex and causes its destabilization. Even a small destabilization of the SNARE complex leads to blocking of the physiological process of tightening facial muscles. Without the possibility of frowning, no wrinkles are created on the face and unwanted facial wrinkles are removed. Wrinkles around the eyes are reduced by up to 17% after 15 days of argireline, and 27% after 30 days’

Molecular weight: 888.99 g/mol

INCI: Water, Acetyl Hexapeptide-8, Phenoxyethanol, Potassium Sorbate

CAS: 616204-22-9, 122-99-6, 24634-61-5, 7732-18-5

 

 

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References:

 

“In vitro skin penetration of acetyl hexapeptide-8 from a cosmetic formulation”- Cutaneous and Ocular Toxicology, March 2015, Pages:46-52

 

“A synthetic hexapeptide (Argireline) with antiwrinkle activity”- International Journal of Cosmetic Science, October 2002, pages 303-310

 

“Argireline: Needle-Free Botox as Analytical Challenge”- Chemistry and Biodiversity, March 2021

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“The anti-wrinkle efficacy of Argireline”- Journal of Cosmetic and Laser Therapy, August 2013;, Pages: 237-241

 

“The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo”-controlled study- American Journal of Clinical Dermatology, April 2013, Pages: 147-153