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Provitamin B5 (synonyms: Panthenol, D-Pantothenyl Alcohol, Dexpanthenol) is an alcoholic analogue of Pantothenic Acid (vitamin B5). Panthenol is an active ingredient that counters inflammation and helps the skin retain moisture.It has two enantiomers, D and L. Only D-panthenol (dexpanthenol) is biologically active, however both forms have the ability to moisturize. For cosmetic use, panthenol can be in D form, or as a racemic mixture of D and L (DL-panthenol). When applied to the skin, it leads to the regeneration of skin cells. Stimulates fibroblast proliferation and regenerates tissue. It attracts moisture from the air and binds it to itself, so it is a good softener. Keeps skin moist and supple and soothes irritated skin.


Molecular weight: 205.25 g/mol


INCI: dl-panthenol


CAS: 81-13-0








“In vivo efficacy and properties of semisolid formulations containing panthenol”- Journal of Cosmetic Dermatology, February 2019, Pages 346-354


“A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora”- Journal of Dermatological Treatment, March 2017, Pages: 173-180


“Skin moisturizing effects of panthenol-based formulations”- Journal of Cosmetic Science, August 2011, Pages361-70.


“The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial”- Indian Journal of dermatology, venereology and leprology, February 2010, Pages: 20-26

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